Infectious Diseases

Welcome to AJAW Hospital's forefront in the battle against infectious diseases. Our pioneering Infectious Disease Department, led by Dr. Aha’u, is dedicated to advancing treatments beyond standard infections, with a particular focus on groundbreaking research targeting HIV, herpes, and long COVID.

At AJAW, our commitment extends to the exploration of innovative therapeutic approaches, notably the use of Latency-Reversing Agents (LRA) to eliminate Viral reservoirs. LRA strategies aim to awaken dormant viral DNA in latent reservoirs, forcing the virus out of resting cells. This two-step process involves reactivating latent viral DNA followed by effectively clearing the infected cells.

Central to this approach are Histone Deacetylase (HDAC) inhibitors, a prominent class of latency-reversing agents. HDAC inhibitors play a pivotal role in inducing the production of viruses from latently infected cells. Within the genome, histones, proteins around which DNA wraps, regulate active gene transcription. In certain genomic regions, chromatin, composed of DNA and associated proteins, is tightly condensed, rendering the DNA inaccessible to the cell's transcription machinery.

This tight chromatin structure is a key mechanism allowing HIV and other viruses to lie dormant in cells. HDAC inhibitors act by relaxing the chromatin, allowing genes in that DNA segment to be activated. This process effectively forces latently infected cells to produce viruses, making them vulnerable to subsequent clearance.

AJAW Hospital's cutting-edge laboratories are equipped with state-of-the-art technology, facilitating in-depth research into the intricate mechanisms of viral latency and the potential of HDAC inhibitors as a revolutionary tool in eliminating HIV reservoirs. Our collaborative efforts with leading institutions and pharmaceutical partners amplify the impact of our research, propelling us towards transformative breakthroughs in infectious disease management.

Join us at AJAW Hospital, where scientific innovation converges with compassionate care, and together, we strive to redefine the boundaries of possibility in the fight against infectious diseases.

If you are infected with HIV, Herpes, or Long Covid please message the chat or email us at info@ajaw.org so we can enroll you in our viral cure trials.